Our brains are only 2% of our weight but account for 20 – 50% of our metabolic demands. The adult body has 6 liters of blood. 1 liter passes through the brain every minute. Mostly, the blood’s job is to carry oxygen and nutrients to the brain. Even though eating well is important for some people, the only effective treatment for suboptimal nutrient availability in the brain is supplementation. The human brain needs a steady supply of micronutrients to function at its best, but many Americans don’t get adequate amounts in their standard diet. Deficiencies in key vitamins and minerals can have a negative impact both on cognitive performance and mood; for example, zinc deficiency can contribute to fatigue and irritability, and a shortage of thiamin may prevent production of important neurotransmitters. Research continues to show that the mind and body thrive when given the nutrients they need. Some people have a higher genetic need for nutrients. The genes for mental illness are likely the genes that regulate brain metabolism of essential nutrients. Many symptoms can be helped.